I was diagnosed with Hepatitis C almost 30 years ago. When Interferon alfa-2b + Ribavirin came out I tried that. After 26 weeks I had to be taken off of it because I thought I was going to kill myself. Unknowingly, the drug had been creeping up on me for at least 3 months, retrospectively. I felt like I was slowly losing my mind and was evidently a bit hallucinogenic, as things didn’t look right, especially when I looked in the mirror. Also, my viral count never got below 70,000 from about 1,200,000.

Then, I was treated with Peg-Interferon alfa-2b + Ribavirin when it became available. I only lasted 12 weeks, because it failed to reduce my viral load, at all. And, at this time my virus count was back up to about 2,000,000.

My viral count was at around 2,000,000, when I was enrolled in a clinical trial of Peg-Interferon alfa-2b + Telaprevir + Ribavirin. This combination reduced my viral load to undetectable status within 8 weeks. Unfortunately, after about 12 weeks the treatment had to be terminated, because I again went completely insane. In a month the viral load was completely back as high as ever.

I have just finished 24 weeks of GS-7977 + Daclatasvir + Ribavirin. The virus was undetectable within 8 weeks and the only side-effects I experienced was being extremely tired. I am currently 9 days post-treatment and I am still very tired. I am told that I will be that way for at least a month, possibly 3 months. I am not sure, but I think tiredness is from anemia caused by the ribavirin. It may turn out that the ribavirin will not be necessary for a successful treatment. I now have follow up for 48 weeks. Hopefully it will stick this time.

Treatment Details

Genotype: 1a

Method / Date of Contraction: Diagnosed in 1982

Treatment History: I was treated initially with Interferon + Ribavirin that resulted in treatment failure and severe psychological side-effects.
Subsequently, treated with Pegylated Interferon + Ribavirin which ended in treatment failure, as well, because of failure to reduce the viral load.
The third treatment consisted of a clinical trial of Pegylated Interferon + Ribavirin + Telaprevir (Incivek). The virus was listed as undetectable within 8 weeks. After 12 weeks, I had to be removed from the protocol due to severe mental side-effects. The virus recovered to pre-treatment levels within 4 weeks.

The fourth treatment was a 24 week course of GS-7977 + Daclatasvir + Ribavirin which I finished in August 2012. The virus was listed undetectable within 8 weeks.

Treatment Issues / Side effects: The only side effect I experienced from the most recent treatment was extreme fatigue.